Nucleotides are the basic components of nucleic acids like DNA and RNA that are involved in many biological processes. Proteins like kinases, topoisomerases, etc, have to recognize nucleotides during their biological action and have a specific site dedicated to this. Mutagens that fit into the space between two adjacent base pairs can be used to block those proteins for therapeutic purposes, for example in chemotherapy.

Aminopyrazoles are described as intercalating agents in nucleic acids and have applications in cancer therapy, anti-bacterials and anti-fungals. Examples of active aminopyrazoles against GPCRs and ion channels can also be found. The compounds were designed to strictly fit the Lipinski rules.

We believe that this library is an efficient tool for the exploration of this pharmacophore, and will be of great help for the discovery of new leads, with the potentiality to quickly generate preliminary SAR.

Feel free to download the pdf brochure and to request a login password to have access to the structures.