The diaminopyrimidine library is specially designed for the interaction with protein kinases. It was experimentally validated in a recent publication (Gozalbes, R. ; Simon, L. ; Froloff, N. ; Sartori, E. ; Monteils, C. ; Baudelle, R. “Development and Experimental Validation of a Docking Strategy for the Generation of Kinase-Targeted Librairies” J. Med. Chem., 2008, 51, 3124-3132). Built on the promiscuous diaminopyrimidine scaffold, several families of kinases could be studied including CTK, CGMC and RTK.

The spirochromanone library and the aryloxypropylamine library are respectively exploring rigid and flexible scaffolds having applications in the field of GPCR and CNS.

A diverse library of indoles and indole surrogates is proposed for first-intention screenings. This library is the first example of our EXPLORA libraries, designed to quickly explore and identify new potential scaffolds in drug discovery.

Finally a fragment library is proposed for NMR and X-ray screenings.

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