The oxazadiazoline library explores an original druglike structure related to oxadiazoles and hydrazones with reported activity in several fields. The compounds could be used for researches in antibiotics and anticancer agents.

Systematic exploration of the alkoxynicotinamide scaffold in the same named library gives opportunities in the field of aminergic and peptidergic GPCRs and for phosphodiesterases inhibition.

We introduce our first ion channel library based on the polyaryl imidazole scaffold. The library was produced using an original connecting chemistry and can also have applications against enzymes like kinases and phosphatases.

Benzimidazoles are known as privileged scaffold interacting with nucleotidic structures and nucleotidic processing enzymes (topoisomerases,DNA and RNA polymerases) and tubulin. Those drug-like structures are of special interest for anti-cancer, anti-parasitic and anti-bacterial leads. The library should be a valuable tool to explore those fields.

Finally we present our second EXPLORA library which focuses on aminopyridines, aminopyrimidines and purine-like structures. Those scaffolds are related to interesting leads for the exploration of the  "kinome" and to natural derivatives with complex pharmacology and are privileged structures for kinase and phosphodiesterase inhibitors and for GPCR agonists and antagonists.

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