Our first pyrazole library was centered on 1-aryl-5-aminopyrazoles for DNA and RNA intercalating agents. Intercalating agents are often planar molecules that disrupt base stacking. The objective of this new library was to substitute the pyrazole with a flexible side chain to obtain molecules able to adapt an enzyme site. Systematic variations around the intermediates allow a quick SAR establishment.
   
Many applications can be considered for this collection of compounds, particularly amine and peptide GPCR inhibition and the identification of new series of non-steroidal anti-inflammatory drugs. Other themes are described in the brochure of the library.

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