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Crystal Structure of ROCK 1 kinase bound to fasudil / Structure of fasudil
Since then, many examples have shown that fragment-based drug discovery is a powerful tool to help medicinal chemists attain optimisation of their molecules. However, no new active compound discovered only with this technique has currently reached the market (meaning connecting two fragments to obtain the lead compound). There is a need for second and third generation fragment compounds to master the hardest part of the technique - the connectivity between the fragments.
FRAGMENT LIBRARY 1
• original scaffolds