> Products > ION CHANNEL LIBRARIES
ION CHANNEL LIBRARIES
Potassium Channel KcsA-Fab complex in Sodium Chloride / Crystal Structure Of Human Potassium Channel Kv Beta-subunit / X-ray structure of a voltage-dependent potassium channel in complex with an Fab
Ion channels are pore-forming proteins present in the membrane of all living cells. They control the flow of charged atoms into and out of the cells. In humans, they are involved in important physiological functions like nervous and muscular cell excitability, hormonal secretion, cell multiplication and apoptosis. Thus, they are also involved in many diseases.
The pore of the channel is surrounded by several identical subunits (usually four) with up to six transmembrane helices each, and external conditions (the gating) make the subunits move to open or close the passage. This superfamily of potential targets has been classified in two main ways: according to the gating (voltage gated, extracellular ligand gated, intracellular ligand gated, other gatings) and according to the type of ion (Cl-, Na+, K+, H+, unspecific).
Interest in ion channels peaked in 1990 with eight NCEs approved on the US market, mainly for hypertension and epilepsy. Since then, progresses in structure crystallisation and determination allowed to better understand the processes involved and to identify the active sites where small molecules could interact.
IMIDAZOLE ACETAMIDE LIBRARY
• highly diverse exploration of imidazole-N-acetamides
• highly diverse exploration of imidazoles, with emphasis on diaryl and triaryl compounds
QUINOLINE CARBOXAMIDE LIBRARY
• first-line and diverse library exploring the quinoline carboxamides