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OTHER THEMES
Please find in this category some new themes that we want to explore. Those themes will become full categories in the future !
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DIHYDROQUINAZOLINONE LIBRARY
• highly diverse exploration of dihydroquinazolinones
• privileged structures for diuretics, analgesics, antibiotics and anti-tumoral compounds
• drug-like structures with reported oral and CNS activities
• systematic preparative LC/MS purification
• library based on a new connecting chemistry
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IMIDAZOLE LIBRARY
• highly diverse exploration of imidazoles, with emphasis on diaryl and triaryl compounds
• condensed imidazole derivatives with reasonable molecular weight
• large array of potential targets: ion channels (GABA subtypes), enzymes, amine and peptide GPCRs
• library based on a new connecting chemistry
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OXAZADIAZOLINE LIBRARY
• privileged structures for antibiotics with unexplored pharmacology space
• druglike structures related to oxadiazoles and hydrazones with reported activities in amine and peptide GPCRs, tubulin binding and angiogenesis inhibition
• fast custom synthesis around specific intermediates
• library based on 11 intermediates
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QUINOLINE CARBOXAMIDE LIBRARY
• first-line and diverse library exploring the quinoline carboxamides
• wide pharmacological spectrum: peptide and amine GPCRs, protein-protein interactions, ion channels and enzyme inhibitors
• many different therapeutic fields including cancer, analgesia and CNS, immunology, cardiovascular, gastrointestinal and pulmonary
• oral activities reported for similar structures
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