This library is centred around 4 and 7-azaindole structures. In collaboration with Provence Technologies, which developed new methodologies for the synthesis of those heterocycles, we designed a collection of compounds suitable for the discovery of new original inhibitors of kinases and other enzymes. Switching from indole to azaindole can improve pharmacokinetic properties and the library could also be useful for the identification of new GPCR inhibitors. More than 44% of the compounds are CNS predicted by our CNS model.