This thematic library is centered around aminopyridine, aminopyrimidine, purine and purine surrogate structures. It is designed to give to the medicinal chemist an efficient tool for the exploration of this versatile pharmacophoric pattern. 48 highly diverse intermediates have been selected and coupled with sets of partners to optimise diversity. The Explora2 library has applications in many fields and is a valuable tool for the exploration of those promiscuous scaffolds.